The Convergence of Stem Cell Therapy and Precision Reproductive Medicine in the Management of Female Infertility

Rimonta Febby Gunanegara; Hanom Husni Syam

doi:10.59890/ijasr.v4i4.233

Authors

Rimonta Febby Gunanegara Maranatha Christian University, Bandung
Hanom Husni Syam Padjadjaran University

DOI:

https://doi.org/10.59890/ijasr.v4i4.233

Keywords:

Female Infertility, Stem Cell Therapy, Precision Reproductive Medicine, Regenerative Medicine, Reproductive Health

Abstract

Female infertility remains a major challenge in reproductive medicine, particularly in cases involving ovarian dysfunction and endometrial disorders. This study aims to examine the potential integration of stem cell therapy and precision reproductive medicine in improving infertility management. A systematic review was conducted using 32 articles published between 2020 and 2024 and retrieved from international scientific databases. Data were collected through literature screening based on predefined inclusion and exclusion criteria and analyzed using thematic synthesis. The findings indicate that stem cell therapy supports reproductive tissue regeneration, while precision reproductive medicine enables individualized treatment based on patient characteristics. Their integration offers a promising approach to improving reproductive outcomes and advancing personalized infertility treatment.

References

Aromataris, E., & Munn, Z. (Eds.). (2020). JBI manual for evidence synthesis. Joanna Briggs Institute.

Ata, B., Capuzzo, M., Turkgeldi, E., Yildiz, S., & La Marca, A. (2022). Individualized ovarian stimulation in assisted reproductive technology: Current concepts and future directions. Frontiers in Endocrinology, 13, 894069. https://doi.org/10.3389/fendo.2022.894069

Capalbo, A., Poli, M., Rienzi, L., Girardi, L., Patassini, C., Fabiani, M., Cimadomo, D., Benini, F., Farcomeni, A., Ubaldi, F. M., & Rubio, C. (2024). Advances in reproductive genetics and precision medicine in assisted reproduction. Human Reproduction Update, 30(1), 1–22. https://doi.org/10.1093/humupd/dmad030

Cui, X., Zhang, H., Liu, Y., & Wang, J. (2024). Stem cell-based therapeutic potential in female ovarian aging and related infertility. Reproductive Biology and Endocrinology, 22(1), 1–15. https://doi.org/10.1186/s12958-024-01492-3

Ding, C., Li, H., Wang, Y., Wang, F., Wu, H., Chen, R., & Huang, B. (2024). Advances in mesenchymal stem cell therapy for premature ovarian insufficiency. Stem Cell Research & Therapy, 15(1), 52–65. https://doi.org/10.1186/s13287-024-03652-5

Esteves, S. C., Roque, M., Bedoschi, G. M., Conforti, A., Humaidan, P., & Alviggi, C. (2021). Defining low prognosis patients undergoing assisted reproductive technology: POSEIDON criteria and its clinical implications. Frontiers in Endocrinology, 12, 587415. https://doi.org/10.3389/fendo.2021.587415

Garrido, N., Zuzuarregui, J. L., Meseguer, M., & Remohí, J. (2024). Biomarkers and precision medicine in reproductive healthcare: Emerging clinical applications. Journal of Assisted Reproduction and Genetics, 41(2), 287–301. https://doi.org/10.1007/s10815-023-02973-2

Gleicher, N., Kushnir, V. A., Barad, D. H., & Darmon, S. K. (2021). The role of personalized reproductive medicine in infertility treatment. Reproductive Biology and Endocrinology, 19(1), 108. https://doi.org/10.1186/s12958-021-00795-9

Guo, C., Ma, Y., Situ, Y., Liu, L., Luo, G., Li, H., Ma, W., Sun, L., Wang, W., Weng, Q., Wu, L., & Fan, D. (2023). Mesenchymal stem cells therapy improves ovarian function in premature ovarian failure: A systematic review and meta-analysis based on preclinical studies. Frontiers in Endocrinology, 14, 1165574. https://doi.org/10.3389/fendo.2023.1165574

Haddaway, N. R., Page, M. J., Pritchard, C. C., & McGuinness, L. A. (2022). PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams. Systematic Reviews, 11(1), 252. https://doi.org/10.1186/s13643-022-02123-0

Hassanpour, H., Shokoohi, M., Abtahi-Eivary, S. H., & Vosough, M. (2023). Stem cell-based therapies for ovarian insufficiency and infertility: Current evidence and future perspectives. Cells, 12(9), 1254. https://doi.org/10.3390/cells12091254

Hu, H. Q., Liu, Y., Zhang, Y., & Wang, X. (2024). Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Current progress and future perspectives. Stem Cell Research & Therapy, 15(1), 1–15.

Hussain, A., Khan, M., & Ahmed, S. (2025). Innovations and challenges in modern infertility treatment. Future Reproductive Health, 3(1), 1–14. https://doi.org/10.1186/s43043-025-00257-2

La Marca, A., & Sunkara, S. K. (2021). Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers. Human Reproduction Update, 27(4), 653–674. https://doi.org/10.1093/humupd/dmab004

Li, Z., Wang, Y., Xiao, K., Xiang, S., Weng, X., & Li, L. (2021). Emerging role of stem cells in ovarian regeneration and fertility restoration. Frontiers in Cell and Developmental Biology, 9, 793067. https://doi.org/10.3389/fcell.2021.793067

Liu, F., Hu, S., Yang, H., Li, Z., Huang, K., Su, T., & Wang, S. (2023). Advances in stem cell therapy for endometrial regeneration and infertility treatment. Frontiers in Cell and Developmental Biology, 11, 1186457. https://doi.org/10.3389/fcell.2023.1186457

Munn, Z., Peters, M. D. J., Stern, C., Tufanaru, C., McArthur, A., & Aromataris, E. (2020). Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Medical Research Methodology, 18(1), 143. https://doi.org/10.1186/s12874-018-0611-x

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., ... Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

Peters, M. D. J., Marnie, C., Tricco, A. C., Pollock, D., Munn, Z., Alexander, L., McInerney, P., Godfrey, C. M., & Khalil, H. (2020). Updated methodological guidance for the conduct of scoping reviews. JBI Evidence Synthesis, 18(10), 2119–2126. https://doi.org/10.11124/JBIES-20-00167

Rienzi, L., Cimadomo, D., Vaiarelli, A., Ubaldi, N., Ubaldi, F. M., & Capalbo, A. (2023). Precision medicine in reproductive healthcare: Opportunities and challenges. Journal of Assisted Reproduction and Genetics, 40(5), 1011–1023. https://doi.org/10.1007/s10815-023-02781-8

Riestenberg, C. K., Gitlin, S. A., & Surrey, E. S. (2023). Emerging technologies and future directions in reproductive medicine. Fertility and Sterility, 120(5), 891–900. https://doi.org/10.1016/j.fertnstert.2023.08.002

Santamaria, X., Cabanillas, S., Cervelló, I., Arbona, C., Raga, F., Ferro, J., Palmero, J., Remohí, J., Pellicer, A., & Simón, C. (2020). Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: A pilot cohort study. Human Reproduction, 35(5), 1083–1093. https://doi.org/10.1093/humrep/deaa053

Simon, A., & Laufer, N. (2023). The future of personalized reproductive medicine and regenerative fertility therapies. Human Reproduction Open, 2023(3), hoad021. https://doi.org/10.1093/hropen/hoad021

Song, Y., An, X., Zhang, L., Fu, M., Peng, J., Han, P., & Xu, Y. (2021). Mesenchymal stem cell therapy for injured endometrium associated with infertility. Stem Cell Research & Therapy, 12(1), 147. https://doi.org/10.1186/s13287-021-02242-8

Sun, B., Ma, Y., Wang, F., Hu, L., Sun, Y., & Yu, X. (2022). Therapeutic potential of mesenchymal stem cell-derived exosomes in ovarian dysfunction. Frontiers in Endocrinology, 13, 864005. https://doi.org/10.3389/fendo.2022.864005

Tan, J., Li, P., Wang, Q., Li, Y., Li, X., Zhao, D., & Xu, X. (2022). Stem cell-based therapies for thin endometrium and recurrent implantation failure: Current evidence and future perspectives. Biomedicines, 10(11), 2798. https://doi.org/10.3390/biomedicines10112798

Tesarik, J. (2022). Patient-tailored reproductive health care. Frontiers in Reproductive Health, 4, 917159. https://doi.org/10.3389/frph.2022.917159

Venetis, C. A., Tarlatzis, B. C., Kolibianakis, E. M., & Bosdou, J. K. (2023). Biomarkers in reproductive medicine: Clinical applications and future perspectives. Fertility and Sterility, 120(3), 456–468. https://doi.org/10.1016/j.fertnstert.2023.04.018

Viotti, M. (2020). Preimplantation genetic testing for chromosomal abnormalities: Aneuploidy, mosaicism, and structural rearrangements. Genes, 11(6), 602. https://doi.org/10.3390/genes11060602

Wang, S., & Sun, M. (2024). Regenerative medicine strategies for female infertility: Progress and challenges. Journal of Clinical Medicine, 13(4), 1182. https://doi.org/10.3390/jcm13041182

World Health Organization. (2023). Infertility prevalence estimates, 1990–2021. World Health Organization.

World Health Organization. (2023, April 4). 1 in 6 people globally affected by infertility.

Xu, H., Sun, Y., Zhang, M., Wang, J., & Zhao, G. (2023). Endometrial regeneration and fertility restoration through stem cell-based interventions. International Journal of Molecular Sciences, 24(8), 7432. https://doi.org/10.3390/ijms24087432

Yang, X., Zhang, Y., Xu, H., & Zhao, W. (2023). Mesenchymal stem cell therapy in ovarian aging and reproductive disorders: Recent advances and clinical prospects. Biomedicines, 11(8), 2214. https://doi.org/10.3390/biomedicines11082214

Zhang, Y., Chen, X., Li, R., Wang, W., & Liu, P. (2024). Emerging regenerative approaches for endometrial dysfunction and infertility treatment. Journal of Clinical Medicine, 13(3), 812. https://doi.org/10.3390/jcm13030812